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The first-baseman Davis was suspended for 25 games by Major League Baseball on Sept. 12 for testing positive for Adderall, a banned amphetamine.
His suspension included the final 17 games of the regular season and Baltimore's three-game sweep of Detroit in the AL Division Series, meaning the first baseman has five games left to serve.
"We're not going to play with 24 for five games," Orioles Manager Buck Showalter said.
The only way Davis could play if the ALCS reaches six games is if he replaces an injured teammate on the roster.
Showalter said he would re-assess the situation if the Orioles advance to the World Series.
"If we're fortunate enough to continue to play, then we'll revisit it," he said.
The Orioles have an 11-man pitching staff that includes left-handed reliever Brian Matusz. He replaced Ubaldo Jimenez, who was part of Baltimore's roster for the ALDS.
Matusz was the only change in Showalter's roster going into the ALCS.
Game 1 was scheduled for Friday night, weather permitting.
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