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Plouffe homered in the fourth before the Orioles went up 11-2 with their most productive inning of the year.
Plouffe was the architect of Obama's 2008 presidential campaign and a top White House adviser as Obama won re-election.
Plouffe will serve as Uber's senior vice president of policy and strategy, bringing a campaign mindset to a company that has faced resistance in some U.S. cities from the taxi industry and regulators.
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